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Target
BRCA1-associated RING domain protein 1
Ligand
BDBM58130
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay
IC50
5350±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay PubChem Bioassay (2011)[AID] 
Target
Name:
BRCA1-associated RING domain protein 1
Synonyms:
BARD-1 | BARD1 | BARD1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86678.08
Organism:
Homo sapiens (Human)
Description:
gi_116241265
Residue:
777
Sequence:
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
  
Inhibitor
Name:
BDBM58130
Synonyms:
(6E)-6-[4-[N'-[(1E)-1-(6-ketocyclohexa-2,4-dien-1-ylidene)ethyl]hydrazino]-6-methyl-1H-pyrimidin-2-ylidene]cyclohexa-2,4-dien-1-one | (6E)-6-[6-methyl-4-[2-[(1E)-1-(6-oxidanylidenecyclohexa-2,4-dien-1-ylidene)ethyl]hydrazinyl]-1H-pyrimidin-2-ylidene]cyclohexa-2,4-dien-1-one | (6E)-6-[6-methyl-4-[2-[(1E)-1-(6-oxocyclohexa-2,4-dien-1-ylidene)ethyl]hydrazinyl]-1H-pyrimidin-2-ylidene]cyclohexa-2,4-dien-1-one | (6E)-6-[6-methyl-4-[[(1E)-1-(6-oxo-1-cyclohexa-2,4-dienylidene)ethyl]hydrazo]-1H-pyrimidin-2-ylidene]-1-cyclohexa-2,4-dienone | MLS000776683 | SMR000413082 | cid_6517668
Type:
Small organic molecule
Emp. Form.:
C19H18N4O2
Mol. Mass.:
334.3718
SMILES:
CC(N=Nc1cc(C)nc(n1)-c1ccccc1O)c1ccccc1O |w:3.3|
Structure:
Search PDB for entries with ligand similarity: