Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77636
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
6750±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77636
Synonyms:
MLS000041617 | N-[2-(5-bromanylfuran-2-yl)-3H-benzimidazol-5-yl]furan-2-carboxamide | N-[2-(5-bromo-2-furanyl)-3H-benzimidazol-5-yl]-2-furancarboxamide | N-[2-(5-bromo-2-furyl)-3H-benzimidazol-5-yl]-2-furamide | N-[2-(5-bromofuran-2-yl)-3H-benzimidazol-5-yl]furan-2-carboxamide | SMR000046148 | cid_665084
Type:
Small organic molecule
Emp. Form.:
C16H10BrN3O3
Mol. Mass.:
372.173
SMILES:
Brc1ccc(o1)-c1nc2ccc(NC(=O)c3ccco3)cc2[nH]1
Structure:
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