Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77646
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
6650±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77646
Synonyms:
MLS000085596 | N-(5-phenyl-1,2,4-thiadiazol-3-yl)-2-thiophenecarboxamide | N-(5-phenyl-1,2,4-thiadiazol-3-yl)thiophene-2-carboxamide | SMR000020531 | cid_2241562
Type:
Small organic molecule
Emp. Form.:
C13H9N3OS2
Mol. Mass.:
287.36
SMILES:
O=C(Nc1nsc(n1)-c1ccccc1)c1cccs1
Structure:
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