Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77649
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
13000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77649
Synonyms:
3-[(2-hydroxy-3-methoxy-benzyl)amino]-2-(m-tolyl)quinazolin-4-one | 3-[(2-hydroxy-3-methoxybenzyl)amino]-2-(3-methylphenyl)quinazolin-4(3H)-one | 3-[(2-hydroxy-3-methoxyphenyl)methylamino]-2-(3-methylphenyl)-4-quinazolinone | 3-[(2-hydroxy-3-methoxyphenyl)methylamino]-2-(3-methylphenyl)quinazolin-4-one | 3-[(3-methoxy-2-oxidanyl-phenyl)methylamino]-2-(3-methylphenyl)quinazolin-4-one | MLS000089767 | SMR000024385 | cid_3245030
Type:
Small organic molecule
Emp. Form.:
C23H21N3O3
Mol. Mass.:
387.4311
SMILES:
COc1cccc(CNn2c(nc3ccccc3c2=O)-c2cccc(C)c2)c1O
Structure:
Search PDB for entries with ligand similarity: