Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77652
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
6520±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77652
Synonyms:
2-(4-thiophen-2-yl-1,3-thiazol-2-yl)isoindole-1,3-dione | 2-(4-thiophen-2-yl-2-thiazolyl)isoindole-1,3-dione | 2-[4-(2-thienyl)-1,3-thiazol-2-yl]-1H-isoindole-1,3(2H)-dione | 2-[4-(2-thienyl)thiazol-2-yl]isoindoline-1,3-quinone | MLS000065394 | SMR000079175 | cid_2220414
Type:
Small organic molecule
Emp. Form.:
C15H8N2O2S2
Mol. Mass.:
312.366
SMILES:
O=C1N(C(=O)c2ccccc12)c1nc(cs1)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: