Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77653
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
32100±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77653
Synonyms:
3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]chromen-2-one | 3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoyl]chromen-2-one | 3-[2-[(4,6-dimethyl-2-pyrimidinyl)thio]-1-oxoethyl]-1-benzopyran-2-one | 3-[2-[(4,6-dimethylpyrimidin-2-yl)thio]acetyl]coumarin | 3-{[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl}-2H-chromen-2-one | MLS000063192 | SMR000074705 | cid_975450
Type:
Small organic molecule
Emp. Form.:
C17H14N2O3S
Mol. Mass.:
326.37
SMILES:
Cc1cc(C)nc(SCC(=O)c2cc3ccccc3oc2=O)n1
Structure:
Search PDB for entries with ligand similarity: