Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77667
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
13300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77667
Synonyms:
5-chloranyl-N-(1,3-thiazol-2-yl)thiophene-2-carboxamide | 5-chloro-N-(1,3-thiazol-2-yl)thiophene-2-carboxamide | 5-chloro-N-(2-thiazolyl)-2-thiophenecarboxamide | 5-chloro-N-thiazol-2-yl-thiophene-2-carboxamide | MLS000100582 | SMR000018382 | cid_3247993
Type:
Small organic molecule
Emp. Form.:
C8H5ClN2OS2
Mol. Mass.:
244.721
SMILES:
Clc1ccc(s1)C(=O)Nc1nccs1
Structure:
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