Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM79893
Substrate
n/a
Meas. Tech.
Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)
IC50
2240±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay (2011)[AID] 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM79893
Synonyms:
(5Z)-2-(3,4-dimethylanilino)-5-[(1-methyl-2-pyrrolyl)methylidene]-4-thiazolone | (5Z)-2-(3,4-dimethylanilino)-5-[(1-methylpyrrol-2-yl)methylene]-2-thiazolin-4-one | (5Z)-2-(3,4-dimethylanilino)-5-[(1-methylpyrrol-2-yl)methylidene]-1,3-thiazol-4-one | (5Z)-2-[(3,4-dimethylphenyl)amino]-5-[(1-methylpyrrol-2-yl)methylidene]-1,3-thiazol-4-one | 2-[(E)-3,4-Dimethyl-phenylimino]-5-[1-(1-methyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-thiazolidin-4-one | MLS000333217 | SMR000436533 | cid_2003091
Type:
Small organic molecule
Emp. Form.:
C17H17N3OS
Mol. Mass.:
311.401
SMILES:
Cc1ccc(NC2=NC(=O)C(S2)=Cc2cccn2C)cc1C |w:12.13,t:6|
Structure:
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