Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80257
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
2020±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80257
Synonyms:
4-(benzalamino)-3-(3-pyridyl)-1H-1,2,4-triazole-5-thione | 4-(benzylideneamino)-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione | 4-[(phenylmethylene)amino]-3-(3-pyridinyl)-1H-1,2,4-triazole-5-thione | 4-[(phenylmethylidene)amino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione | 4-{[1-Phenyl-meth-(E)-ylidene]-amino}-5-pyridin-3-yl-4H-[1,2,4]triazole-3-thiol | MLS000768120 | SMR000431502 | cid_668524
Type:
Small organic molecule
Emp. Form.:
C14H11N5S
Mol. Mass.:
281.336
SMILES:
S=c1[nH]nc(-c2cccnc2)n1N=Cc1ccccc1 |w:12.13|
Structure:
