Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80300
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1500±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80300
Synonyms:
4-(4-bromophenyl)-3-(2-furanyl)-1H-1,2,4-triazole-5-thione | 4-(4-bromophenyl)-3-(2-furyl)-1H-1,2,4-triazole-5-thione | 4-(4-bromophenyl)-3-(furan-2-yl)-1H-1,2,4-triazole-5-thione | 4-(4-bromophenyl)-5-(2-furyl)-4H-1,2,4-triazol-3-yl hydrosulfide | MLS001178920 | SMR000476469 | cid_854681
Type:
Small organic molecule
Emp. Form.:
C12H8BrN3OS
Mol. Mass.:
322.18
SMILES:
Brc1ccc(cc1)-n1c(n[nH]c1=S)-c1ccco1
Structure:
