Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80235
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen
Temperature
298.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80235
Synonyms:
4-[(3-chlorobenzylidene)amino]-3-(2-pyridyl)-1H-1,2,4-triazole-5-thione | 4-[(3-chlorophenyl)methylideneamino]-3-(2-pyridinyl)-1H-1,2,4-triazole-5-thione | 4-[(3-chlorophenyl)methylideneamino]-3-pyridin-2-yl-1H-1,2,4-triazole-5-thione | MLS001033203 | SMR000363706 | cid_2453434
Type:
Small organic molecule
Emp. Form.:
C14H10ClN5S
Mol. Mass.:
315.781
SMILES:
Clc1cccc(C=Nn2c(n[nH]c2=S)-c2ccccn2)c1 |w:7.7|
Structure:
