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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80457
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2200±222 nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM80457
Synonyms:
2-[(4Z)-4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(4-fluorophenyl)acetamide | 2-[(4Z)-4-[(1-ethyl-2,5-dimethyl-pyrrol-3-yl)methylene]-2,5-diketo-imidazolidin-1-yl]-N-(4-fluorophenyl)acetamide | 2-[(4Z)-4-[(1-ethyl-2,5-dimethyl-pyrrol-3-yl)methylidene]-2,5-bis(oxidanylidene)imidazolidin-1-yl]-N-(4-fluorophenyl)ethanamide | 2-[(4Z)-4-[(1-ethyl-2,5-dimethylpyrrol-3-yl)methylidene]-2,5-dioxoimidazolidin-1-yl]-N-(4-fluorophenyl)acetamide | 2-{4-[(1-ethyl-2,5-dimethyl-1H-pyrrol-3-yl)methylene]-2,5-dioxo-1-imidazolidinyl}-N-(4-fluorophenyl)acetamide | MLS000697981 | SMR000226517 | cid_6294434
Type:
Small organic molecule
Emp. Form.:
C20H21FN4O3
Mol. Mass.:
384.4041
SMILES:
CCn1c(C)cc(\C=C2/NC(=O)N(CC(=O)Nc3ccc(F)cc3)C2=O)c1C
Structure:
Search PDB for entries with ligand similarity: