Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM61351
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2400±208 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM61351
Synonyms:
1-[2-(acetyloxy)-2-phenylethyl]-1-methylazepanium | MLS001196933 | SMR000555824 | [2-(1-methylazepan-1-ium-1-yl)-1-phenyl-ethyl] ethanoate;iodide | [2-(1-methylazepan-1-ium-1-yl)-1-phenylethyl] acetate;iodide | acetic acid [2-(1-methyl-1-azepan-1-iumyl)-1-phenylethyl] ester;iodide | acetic acid [2-(1-methylazepan-1-ium-1-yl)-1-phenyl-ethyl] ester;iodide | cid_24761196
Type:
Small organic molecule
Emp. Form.:
C17H26NO2
Mol. Mass.:
276.3933
SMILES:
CC(=O)OC(C[N+]1(C)CCCCCC1)c1ccccc1
Structure:
