Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80592
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2020±138 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80592
Synonyms:
2-[2-methoxy-4-[(E)-2-(1-methyl-4-pyridin-1-iumyl)ethenyl]phenoxy]-N-phenylacetamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]phenoxy]-N-phenyl-ethanamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]phenoxy]-N-phenylacetamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-4-yl)vinyl]phenoxy]-N-phenyl-acetamide;iodide | 4-[(E)-2-(3-Methoxy-4-phenylcarbamoylmethoxy-phenyl)-vinyl]-1-methyl-pyridinium | MLS001216925 | SMR000605588 | cid_24792747
Type:
Small organic molecule
Emp. Form.:
C23H23N2O3
Mol. Mass.:
375.4398
SMILES:
COc1cc(\C=C\c2cc[n+](C)cc2)ccc1OCC(=O)Nc1ccccc1
Structure:
