Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM61268
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
2020±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM61268
Synonyms:
1-methyl-4-(4-pyridyl)pyridin-1-ium;iodide | 1-methyl-4-pyridin-4-yl-pyridin-1-ium;iodide | 1-methyl-4-pyridin-4-ylpyridin-1-ium;iodide | MLS000037873 | SMR000057824 | cid_38115
Type:
Small organic molecule
Emp. Form.:
C11H11N2
Mol. Mass.:
171.2179
SMILES:
C[n+]1ccc(cc1)-c1ccncc1
Structure:
