Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80392
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1610±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80392
Synonyms:
1-phenyl-1-cyclopentanecarboxylic acid 3-(4-methyl-4-morpholin-4-iumyl)propyl ester;iodide | 1-phenylcyclopentanecarboxylic acid 3-(4-methylmorpholin-4-ium-4-yl)propyl ester;iodide | 3-(4-methylmorpholin-4-ium-4-yl)propyl 1-phenylcyclopentane-1-carboxylate;iodide | MLS000519370 | SMR000129789 | cid_9550057
Type:
Small organic molecule
Emp. Form.:
C20H30NO3
Mol. Mass.:
332.4566
SMILES:
C[N+]1(CCCOC(=O)C2(CCCC2)c2ccccc2)CCOCC1
Structure:
