Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM40679
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1510±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM40679
Synonyms:
1-ethyl-2,6-dimethyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2-ium iodide | 1-ethyl-2,6-dimethyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2-ium;iodide | MLS000532590 | SMR000137529 | cid_2826925
Type:
Small organic molecule
Emp. Form.:
C11H17N2
Mol. Mass.:
177.2655
SMILES:
CCC1=[N+](C)CCn2c(C)ccc12 |c:2|
Structure:
