Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80399
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1270±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80399
Synonyms:
2-(4-methyl-4-morpholin-4-iumyl)acetic acid 3-phenylpropyl ester;iodide | 2-(4-methylmorpholin-4-ium-4-yl)acetic acid 3-phenylpropyl ester;iodide | 3-phenylpropyl 2-(4-methylmorpholin-4-ium-4-yl)acetate;iodide | 3-phenylpropyl 2-(4-methylmorpholin-4-ium-4-yl)ethanoate;iodide | MLS000519387 | SMR000129806 | cid_9551070
Type:
Small organic molecule
Emp. Form.:
C16H24NO3
Mol. Mass.:
278.3661
SMILES:
C[N+]1(CC(=O)OCCCc2ccccc2)CCOCC1
Structure:
