Reaction Details Report a problem with these data
Target
DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80457
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1240±n/a nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
  
Inhibitor
Name:
BDBM80457
Synonyms:
2-[(4Z)-4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(4-fluorophenyl)acetamide | 2-[(4Z)-4-[(1-ethyl-2,5-dimethyl-pyrrol-3-yl)methylene]-2,5-diketo-imidazolidin-1-yl]-N-(4-fluorophenyl)acetamide | 2-[(4Z)-4-[(1-ethyl-2,5-dimethyl-pyrrol-3-yl)methylidene]-2,5-bis(oxidanylidene)imidazolidin-1-yl]-N-(4-fluorophenyl)ethanamide | 2-[(4Z)-4-[(1-ethyl-2,5-dimethylpyrrol-3-yl)methylidene]-2,5-dioxoimidazolidin-1-yl]-N-(4-fluorophenyl)acetamide | 2-{4-[(1-ethyl-2,5-dimethyl-1H-pyrrol-3-yl)methylene]-2,5-dioxo-1-imidazolidinyl}-N-(4-fluorophenyl)acetamide | MLS000697981 | SMR000226517 | cid_6294434
Type:
Small organic molecule
Emp. Form.:
C20H21FN4O3
Mol. Mass.:
384.4041
SMILES:
CCn1c(C)cc(\C=C2/NC(=O)N(CC(=O)Nc3ccc(F)cc3)C2=O)c1C
Structure:
Search PDB for entries with ligand similarity: