Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80503
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1440±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80503
Synonyms:
MLS000687217 | N-(2-methyl-3-octyl-1-phenyl-5-benzimidazol-3-iumyl)acetamide;iodide | N-(2-methyl-3-octyl-1-phenyl-benzimidazol-3-ium-5-yl)acetamide;iodide | N-(2-methyl-3-octyl-1-phenyl-benzimidazol-3-ium-5-yl)ethanamide;iodide | N-(2-methyl-3-octyl-1-phenylbenzimidazol-3-ium-5-yl)acetamide;iodide | SMR000283917 | cid_16193867
Type:
Small organic molecule
Emp. Form.:
C24H32N3O
Mol. Mass.:
378.5298
SMILES:
CCCCCCCCn1c(C)[n+](-c2ccccc2)c2ccc(NC(C)=O)cc12
Structure:
