Reaction Details
Report a problem with these data
Report a problem with these dataTarget
DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM61377
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1560±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM61377
Synonyms:
2-[2-methoxy-4-[(E)-2-(1-methyl-2-pyridin-1-iumyl)ethenyl]phenoxy]-N-(2-methylphenyl)acetamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-2-yl)ethenyl]phenoxy]-N-(2-methylphenyl)acetamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-2-yl)ethenyl]phenoxy]-N-(2-methylphenyl)ethanamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-2-yl)vinyl]phenoxy]-N-(o-tolyl)acetamide;iodide | 2-{(E)-2-[3-Methoxy-4-(o-tolylcarbamoyl-methoxy)-phenyl]-vinyl}-1-methyl-pyridinium | MLS001216975 | SMR000605599 | cid_24792360
Type:
Small organic molecule
Emp. Form.:
C24H25N2O3
Mol. Mass.:
389.4664
SMILES:
COc1cc(\C=C\c2cccc[n+]2C)ccc1OCC(=O)Nc1ccccc1C
Structure:
