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Target
Tropomyosin alpha-1 chain
Ligand
BDBM80827
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
IC50
7597±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM80827
Synonyms:
(6E)-2-methoxy-6-[([1,2,4]triazolo[4,3-a]quinoxalin-4-ylhydrazo)methylidene]-1-cyclohexa-2,4-dienone | (6E)-2-methoxy-6-[[2-([1,2,4]triazolo[4,3-a]quinoxalin-4-yl)hydrazinyl]methylidene]cyclohexa-2,4-dien-1-one | (6E)-2-methoxy-6-[[N'-([1,2,4]triazolo[4,3-a]quinoxalin-4-yl)hydrazino]methylene]cyclohexa-2,4-dien-1-one | 2-Methoxy-6-([1,2,4]triazolo[4,3-a]quinoxalin-4-yl-hydrazonomethyl)-phenol | MLS000589406 | SMR000212768 | cid_5933583
Type:
Small organic molecule
Emp. Form.:
C17H14N6O2
Mol. Mass.:
334.3321
SMILES:
COc1cccc(CN=Nc2nc3ccccc3n3cnnc23)c1O |w:9.9|
Structure:
Search PDB for entries with ligand similarity: