Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM50647
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
IC50
3615±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM50647
Synonyms:
2,3,4,5-tetrahydroxy-6-benzo[7]annulenone | 2,3,4,5-tetrahydroxybenzo[7]annulen-6-one | 2,3,4,5-tetrahydroxybenzocyclohepten-6-one | 2,3,4,5-tetrakis(oxidanyl)benzo[7]annulen-6-one | MLS000738105 | SMR000393869 | cid_5281571
Type:
Small organic molecule
Emp. Form.:
C11H8O5
Mol. Mass.:
220.1782
SMILES:
Oc1cc2cccc(=O)c(O)c2c(O)c1O
Structure:
Search PDB for entries with ligand similarity: