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Target
Tropomyosin alpha-1 chain
Ligand
BDBM80830
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
IC50
8598±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM80830
Synonyms:
4-[(2-oxo-1-carbazolyl)hydrazo]benzenecarboximidamide | 4-[2-(2-oxidanylidenecarbazol-1-yl)hydrazinyl]benzenecarboximidamide | 4-[2-(2-oxocarbazol-1-yl)hydrazinyl]benzenecarboximidamide | 4-[N'-(2-ketocarbazol-1-yl)hydrazino]benzamidine | MLS002701853 | SMR001565445 | cid_5477815
Type:
Small organic molecule
Emp. Form.:
C19H15N5O
Mol. Mass.:
329.3553
SMILES:
NC(=N)c1ccc(cc1)N=Nc1c(O)ccc2c3ccccc3[nH]c12 |w:10.11|
Structure:
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