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Target
Cysteine protease ATG4B
Ligand
BDBM80868
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
870±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM80868
Synonyms:
MLS000582413 | N-(3-chloranyl-2-pyrrolidin-1-yl-phenyl)-3-(2-oxidanylidenechromen-3-yl)benzamide | N-(3-chloro-2-pyrrolidin-1-ylphenyl)-3-(2-oxochromen-3-yl)benzamide | N-(3-chloro-2-pyrrolidino-phenyl)-3-(2-ketochromen-3-yl)benzamide | N-[3-chloro-2-(1-pyrrolidinyl)phenyl]-3-(2-oxo-1-benzopyran-3-yl)benzamide | N-[3-chloro-2-(1-pyrrolidinyl)phenyl]-3-(2-oxo-2H-chromen-3-yl)benzamide | SMR000200958 | cid_2301800
Type:
Small organic molecule
Emp. Form.:
C26H21ClN2O3
Mol. Mass.:
444.91
SMILES:
Clc1cccc(NC(=O)c2cccc(c2)-c2cc3ccccc3oc2=O)c1N1CCCC1
Structure:
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