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Target
Cysteine protease ATG4B
Ligand
BDBM80897
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
5450±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM80897
Synonyms:
2-[(2,6-diketo-4,4-dimethyl-cyclohexylidene)methylamino]-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester | 2-[(4,4-Dimethyl-2,6-dioxo-cyclohexylidenemethyl)-amino]-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester | 2-[(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino]-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester | MLS000590138 | SMR000219397 | cid_3522326 | ethyl 2-[(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino]-4,5-dimethylthiophene-3-carboxylate | ethyl 2-[[4,4-dimethyl-2,6-bis(oxidanylidene)cyclohexylidene]methylamino]-4,5-dimethyl-thiophene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H23NO4S
Mol. Mass.:
349.445
SMILES:
[#6]-[#6]-[#8]-[#6](=O)-c1c(-[#6])c(-[#6])sc1-[#7]\[#6]=[#6]-1/[#6](=O)-[#6]C([#6])([#6])[#6]-[#6]-1=O
Structure:
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