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Target
Cysteine protease ATG4B
Ligand
BDBM80988
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
3470±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM80988
Synonyms:
(5Z)-5-(3,5-dichloro-2-hydroxy-benzylidene)-2-thioxo-thiazolidin-4-one | (5Z)-5-[(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-sulfanylidene-4-thiazolidinone | (5Z)-5-[[3,5-bis(chloranyl)-2-oxidanyl-phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | MLS002608602 | SMR001527349 | cid_5712384
Type:
Small organic molecule
Emp. Form.:
C10H5Cl2NO2S2
Mol. Mass.:
306.188
SMILES:
Oc1c(Cl)cc(Cl)cc1C=C1SC(S)=NC1=O |w:9.9,c:14|
Structure:
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