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Target
cAMP-dependent protein kinase type I-alpha regulatory subunit
Ligand
BDBM81288
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay for activators of the Protein Kinase A-R1A (PKA-R1A) complex
EC50
7827±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for activators of the Protein Kinase A-R1A (PKA-R1A) complex PubChem Bioassay (2011)[AID] 
Target
Name:
cAMP-dependent protein kinase type I-alpha regulatory subunit
Synonyms:
KAP0_BOVIN | PRKAR1A | cAMP-dependent protein kinase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42885.14
Organism:
Bos taurus
Description:
gi_115496662
Residue:
380
Sequence:
MASGTTASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFEKLEKEEAKQIQNLQKAGSRADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV
  
Inhibitor
Name:
BDBM81288
Synonyms:
8-Bromoguanosine 3',5'-cyclic monophosphate sodium salt | MLS000860011 | SMR000326870 | cid_23702959 | sodium;9-[(4aR,6R,7R,7aS)-2-oxidanidyl-7-oxidanyl-2-oxidanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-azanyl-8-bromanyl-3H-purin-6-one | sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-keto-2-oxido-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-6-yl]-2-amino-8-bromo-3H-purin-6-one | sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-bromo-3H-purin-6-one | sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-6-yl]-2-amino-8-bromo-3H-purin-6-one
Type:
Small organic molecule
Emp. Form.:
C10H10BrN5O7P
Mol. Mass.:
423.094
SMILES:
Nc1nc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: