Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM81332
Substrate
n/a
Meas. Tech.
Fluorescent Competition Assay
pH
7.5±0
IC50
1.5e+4±n/a nM
Kd
15.6±5.7 nM
Citation
 Läppchen, T; Pinas, VA; Hartog, AF; Koomen, GJ; Schaffner-Barbero, C; Andreu, JM; Trambaiolo, D; Löwe, J; Juhem, A; Popov, AV; den Blaauwen, T Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites. Chem Biol 15:189-99 (2008) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_AQUAE | ftsZ
Type:
Protein
Mol. Mass.:
40146.54
Organism:
Aquifex aeolicus
Description:
O66809
Residue:
367
Sequence:
MEEFVNPCKIKVIGVGGGGSNAVNRMYEDGIEGVELYAINTDVQHLSTLKVPNKIQIGEKVTRGLGAGAKPEVGEEAALEDIDKIKEILRDTDMVFISAGLGGGTGTGAAPVIAKTAKEMGILTVAVATLPFRFEGPRKMEKALKGLEKLKESSDAYIVIHNDKIKELSNRTLTIKDAFKEVDSVLSKAVRGITSIVVTPAVINVDFADVRTTLEEGGLSIIGMGEGRGDEKADIAVEKAVTSPLLEGNTIEGARRLLVTIWTSEDIPYDIVDEVMERIHSKVHPEAEIIFGAVLEPQEQDFIRVAIVATDFPEEKFQVGEKEVKFKVIKKEEKEEPKEEPKPLSDTTYLEEEEIPAVIRRKNKRLL
  
Inhibitor
Name:
BDBM81332
Synonyms:
PyrrGTP (7b)
Type:
Small organic molecule
Emp. Form.:
C14H20N6O14P3
Mol. Mass.:
589.2633
SMILES:
Nc1nc2n([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C3O)c(nc2c(=O)[nH]1)N1CCCC1 |r|
Structure:
Search PDB for entries with ligand similarity: