Target
Hypoxia-inducible factor 1-alpha
Ligand
BDBM66087
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
4.5e+3± 5e+2 nM
Citation
 Smirnova, NARakhman, IMoroz, NBasso, MPayappilly, JKazakov, SHernandez-Guzman, FGaisina, INKozikowski, APRatan, RRGazaryan, IG Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol 17:380-91 (2010) [PubMed]  Article 
Target
Name:
Hypoxia-inducible factor 1-alpha
Synonyms:
BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A
Type:
Protein
Mol. Mass.:
92647.24
Organism:
Homo sapiens (Human)
Description:
Q16665
Residue:
826
Sequence:
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
  
Inhibitor
Name:
BDBM66087
Synonyms:
2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone | 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridone | 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one | 2-azanylethanol;6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one | Ciclopirox | Ciclopirox ethanolamine | MLS002153867 | SMR001233223 | cid_38911
Type:
Small organic molecule
Emp. Form.:
C12H17NO2
Mol. Mass.:
207.2689
SMILES:
Cc1cc(C2CCCCC2)n(O)c(=O)c1
Structure:
Search PDB for entries with ligand similarity: