Reaction Details
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Report a problem with these dataTarget
Histamine H1 receptor
Ligand
BDBM50329371
Substrate
n/a
Ki
9±n/a nM
Comments
PDSP_507
Citation
Tran, VT; Chang, RS; Snyder, SH Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proc Natl Acad Sci U S A 75:6290-4 (1978) [PubMed] Article More Info.:
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
Inhibitor
Name:
BDBM50329371
Synonyms:
1-((4-chlorophenyl)(phenyl)methyl)-4-methylpiperazine | 1-[(4-Chloro-phenyl)-phenyl-methyl]-4-methyl-piperazine | CHEMBL22150 | chlorcyclizine
Type:
Small organic molecule
Emp. Form.:
C18H21ClN2
Mol. Mass.:
300.826
SMILES:
CN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1
Structure:
