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TargetAcrAB-TolC
LigandBDBM81507
Substrate/Competitorn/a
Meas. Tech.Binding Assay
pH7.5±0
Kd 590000±0.0 nM
Citation Tikhonova, EBYamada, YZgurskaya, HI Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC. Chem Biol18:454-63 (2011) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
AcrAB-TolC
Name:AcrAB-TolC
Synonyms:AcrAB-TolC multidrug efflux transport system | Acriflavine resistance protein B | Multidrug efflux system protein | Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family
Type:Protein
Mol. Mass.:113561.74
Organism:Escherichia coli
Description:C6EL02
Residue:1049
Sequence:
MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT
VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ
EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS
QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL
TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL
DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ
NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM
AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL
SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR
YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT
KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD
AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG
LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR
MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA
MELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFS
VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL
IEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIF
FVPVFFVVVRRRFSRKNEDIEHSHTVDHH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM81507
NameBDBM81507
Synonyms:MC-207,110
TypeSmall organic molecule
Emp. Form.C25H30N6O2
Mol. Mass.446.5447
SMILES[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c1ccc2ccccc2c1 |r|
Structure
n/a