Reaction Details Report a problem with these data
Target
Leucyl-cystinyl aminopeptidase
Ligand
BDBM271190
Substrate
n/a
Meas. Tech.
Inhibition of IRAP Assay
IC50
1.20±n/a nM
Citation
 Kawaguchi, K; Ishihata, A; Inagaki, Y; Tsuchiya, K; Hanadate, T; Kanai, A; Kaizawa, H; Kazami, J; Morikawa, H; Hiramoto, M; Enjo, K; Takamatsu, H Pyridine derivative US Patent  US10059720 Publication Date 8/28/2018 
Target
Name:
Leucyl-cystinyl aminopeptidase
Synonyms:
Cystinyl aminopeptidase | GP160 | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Irap | LCAP_RAT | Leucyl-cystinyl aminopeptidase | Lnpep | Otase | Oxytocinase | P-LAP | Placental leucine aminopeptidase | Vesicle protein of 165 kDa | Vp165
Type:
PROTEIN
Mol. Mass.:
117179.39
Organism:
Rattus norvegicus
Description:
ChEMBL_98523
Residue:
1025
Sequence:
METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL
  
Inhibitor
Name:
BDBM271190
Synonyms:
US10059720, Example 6 | US10975091, Example 6
Type:
Small organic molecule
Emp. Form.:
C20H32N2O4
Mol. Mass.:
364.4791
SMILES:
CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Structure:
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