Target
Leucyl-cystinyl aminopeptidase
Ligand
BDBM271310
Substrate
n/a
Meas. Tech.
Inhibition of IRAP Assay
IC50
0.900±n/a nM
Citation
 Kawaguchi, KIshihata, AInagaki, YTsuchiya, KHanadate, TKanai, AKaizawa, HKazami, JMorikawa, HHiramoto, MEnjo, KTakamatsu, H Pyridine derivative US Patent  US10059720 Publication Date 8/28/2018 
Target
Name:
Leucyl-cystinyl aminopeptidase
Synonyms:
Cystinyl aminopeptidase | GP160 | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Irap | LCAP_RAT | Leucyl-cystinyl aminopeptidase | Lnpep | Otase | Oxytocinase | P-LAP | Placental leucine aminopeptidase | Vesicle protein of 165 kDa | Vp165
Type:
PROTEIN
Mol. Mass.:
117179.39
Organism:
Rattus norvegicus
Description:
ChEMBL_98523
Residue:
1025
Sequence:
METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL
  
Inhibitor
Name:
BDBM271310
Synonyms:
US10059720, Example 125 | US10975091, Example 125
Type:
Small organic molecule
Emp. Form.:
C20H31FN2O4
Mol. Mass.:
382.4695
SMILES:
C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-2.31,;-6,-4.62,;-7.34,-3.85,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Structure:
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