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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM82692
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
1700±134 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM82692
Synonyms:
3-(3-nitrophenyl)-N'-[(1E)-1-(6-oxidanylidenecyclohexa-2,4-dien-1-ylidene)ethyl]-1H-pyrazole-5-carbohydrazide | 3-(3-nitrophenyl)-N'-[(1E)-1-(6-oxo-1-cyclohexa-2,4-dienylidene)ethyl]-1H-pyrazole-5-carbohydrazide | 3-(3-nitrophenyl)-N'-[(1E)-1-(6-oxocyclohexa-2,4-dien-1-ylidene)ethyl]-1H-pyrazole-5-carbohydrazide | MLS000571742 | N'-[1-(2-hydroxyphenyl)ethylidene]-3-(3-nitrophenyl)-1H-pyrazole-5-carbohydrazide | N'-[(1E)-1-(6-ketocyclohexa-2,4-dien-1-ylidene)ethyl]-3-(3-nitrophenyl)-1H-pyrazole-5-carbohydrazide | SMR000193754 | cid_5345538
Type:
Small organic molecule
Emp. Form.:
C18H15N5O4
Mol. Mass.:
365.3428
SMILES:
CC(=[NH+]NC(=O)c1cc(n[nH]1)-c1cccc(c1)[N+]([O-])=O)[c-]1ccccc1=O |w:2.2|
Structure:
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