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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM83061
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
1396±114 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM83061
Synonyms:
2-chlorobenzoic acid [4-[[(3,5-dihydroxybenzoyl)hydrazono]methyl]phenyl] ester | 2-chlorobenzoic acid [4-[[[(3,5-dihydroxyphenyl)-oxomethyl]hydrazinylidene]methyl]phenyl] ester | MLS001224213 | SMR000678821 | [4-[[(3,5-dihydroxybenzoyl)hydrazinylidene]methyl]phenyl] 2-chlorobenzoate | [4-[[[3,5-bis(oxidanyl)phenyl]carbonylhydrazinylidene]methyl]phenyl] 2-chloranylbenzoate | cid_24820053
Type:
Small organic molecule
Emp. Form.:
C21H15ClN2O5
Mol. Mass.:
410.807
SMILES:
Oc1cc(O)cc(c1)C(=O)NN=Cc1ccc(OC(=O)c2ccccc2Cl)cc1
Structure:
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