Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM80006
Substrate
n/a
Meas. Tech.
SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay
IC50
14800±n/a nM
Citation
 PubChem, PC SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay PubChem Bioassay (2011)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM80006
Synonyms:
2,5-diphenyl-N'-(phenylcarbonyl)pyrazole-3-carbohydrazide | MLS000388665 | N'-benzoyl-2,5-diphenyl-3-pyrazolecarbohydrazide | N'-benzoyl-2,5-diphenyl-pyrazole-3-carbohydrazide | N'-benzoyl-2,5-diphenylpyrazole-3-carbohydrazide | SMR000254838 | cid_4883406
Type:
Small organic molecule
Emp. Form.:
C23H18N4O2
Mol. Mass.:
382.4146
SMILES:
O=C(NNC(=O)c1ccccc1)c1cc(nn1-c1ccccc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: