Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM80868
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
978±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM80868
Synonyms:
MLS000582413 | N-(3-chloranyl-2-pyrrolidin-1-yl-phenyl)-3-(2-oxidanylidenechromen-3-yl)benzamide | N-(3-chloro-2-pyrrolidin-1-ylphenyl)-3-(2-oxochromen-3-yl)benzamide | N-(3-chloro-2-pyrrolidino-phenyl)-3-(2-ketochromen-3-yl)benzamide | N-[3-chloro-2-(1-pyrrolidinyl)phenyl]-3-(2-oxo-1-benzopyran-3-yl)benzamide | N-[3-chloro-2-(1-pyrrolidinyl)phenyl]-3-(2-oxo-2H-chromen-3-yl)benzamide | SMR000200958 | cid_2301800
Type:
Small organic molecule
Emp. Form.:
C26H21ClN2O3
Mol. Mass.:
444.91
SMILES:
Clc1cccc(NC(=O)c2cccc(c2)-c2cc3ccccc3oc2=O)c1N1CCCC1
Structure:
Search PDB for entries with ligand similarity: