Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM80897
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
5120±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM80897
Synonyms:
2-[(2,6-diketo-4,4-dimethyl-cyclohexylidene)methylamino]-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester | 2-[(4,4-Dimethyl-2,6-dioxo-cyclohexylidenemethyl)-amino]-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester | 2-[(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino]-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester | MLS000590138 | SMR000219397 | cid_3522326 | ethyl 2-[(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino]-4,5-dimethylthiophene-3-carboxylate | ethyl 2-[[4,4-dimethyl-2,6-bis(oxidanylidene)cyclohexylidene]methylamino]-4,5-dimethyl-thiophene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H23NO4S
Mol. Mass.:
349.445
SMILES:
[#6]-[#6]-[#8]-[#6](=O)-c1c(-[#6])c(-[#6])sc1-[#7]\[#6]=[#6]-1/[#6](=O)-[#6]C([#6])([#6])[#6]-[#6]-1=O
Structure:
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