Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM55197
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
1190±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM55197
Synonyms:
2-[5-(3,4-Dimethoxy-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-3-isobutyl-3H-quinazolin-4-one | 2-[[5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-3-(2-methylpropyl)quinazolin-4-one | 2-[[5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]methylthio]-3-(2-methylpropyl)-4-quinazolinone | 2-[[5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]methylthio]-3-isobutyl-quinazolin-4-one | MLS000072736 | SMR000003662 | cid_650282
Type:
Small organic molecule
Emp. Form.:
C23H24N4O4S
Mol. Mass.:
452.526
SMILES:
COc1ccc(cc1OC)-c1nnc(CSc2nc3ccccc3c(=O)n2CC(C)C)o1
Structure:
Search PDB for entries with ligand similarity: