Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM58388
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
4680±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM58388
Synonyms:
((5E)-5-{5-bromo-2-[(4-chlorobenzyl)oxy]benzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acid | 2-[(5E)-5-[5-bromo-2-(4-chlorobenzyl)oxy-benzylidene]-4-keto-2-thioxo-thiazolidin-3-yl]acetic acid | 2-[(5E)-5-[[5-bromanyl-2-[(4-chlorophenyl)methoxy]phenyl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanoic acid | 2-[(5E)-5-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid | 2-[(5E)-5-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]acetic acid | MLS001194458 | SMR000555238 | cid_1326684
Type:
Small organic molecule
Emp. Form.:
C19H13BrClNO4S2
Mol. Mass.:
498.798
SMILES:
OC(=O)CN1C(=S)S\C(=C\c2cc(Br)ccc2OCc2ccc(Cl)cc2)C1=O
Structure:
Search PDB for entries with ligand similarity: