Target
Delta-type opioid receptor
Ligand
BDBM83369
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay
EC50
20454±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRD1 homodimerization PubChem Bioassay (2011)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM83369
Synonyms:
1-(3-chlorophenyl)-3-[2-(dimethylamino)-2-(3-pyridinyl)ethyl]thiourea | 1-(3-chlorophenyl)-3-[2-(dimethylamino)-2-(3-pyridyl)ethyl]thiourea | 1-(3-chlorophenyl)-3-[2-(dimethylamino)-2-pyridin-3-yl-ethyl]thiourea | 1-(3-chlorophenyl)-3-[2-(dimethylamino)-2-pyridin-3-ylethyl]thiourea | MLS000730945 | N-(3-chlorophenyl)-N'-[2-(dimethylamino)-2-pyridin-3-ylethyl]thiourea | SMR000309320 | cid_5113104
Type:
Small organic molecule
Emp. Form.:
C16H19ClN4S
Mol. Mass.:
334.867
SMILES:
CN(C)C(CNC(=S)Nc1cccc(Cl)c1)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: