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Target
Delta-type opioid receptor
Ligand
BDBM83378
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay
EC50
26946±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRD1 homodimerization PubChem Bioassay (2011)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM83378
Synonyms:
5-bromanyl-N-[2-(dimethylamino)-2-(4-methoxyphenyl)ethyl]pyridine-3-carboxamide | 5-bromo-N-[2-(dimethylamino)-2-(4-methoxyphenyl)ethyl]-3-pyridinecarboxamide | 5-bromo-N-[2-(dimethylamino)-2-(4-methoxyphenyl)ethyl]nicotinamide | 5-bromo-N-[2-(dimethylamino)-2-(4-methoxyphenyl)ethyl]pyridine-3-carboxamide | MLS000772002 | SMR000376609 | cid_4881395
Type:
Small organic molecule
Emp. Form.:
C17H20BrN3O2
Mol. Mass.:
378.264
SMILES:
COc1ccc(cc1)C(CNC(=O)c1cncc(Br)c1)N(C)C
Structure:
Search PDB for entries with ligand similarity: