Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM32010
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
46700±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM32010
Synonyms:
(4Z)-4-[[4-(dimethylamino)anilino]methylene]-2-phenyl-2-oxazolin-5-one | (4Z)-4-[[4-(dimethylamino)anilino]methylidene]-2-phenyl-1,3-oxazol-5-one | (4Z)-4-[[4-(dimethylamino)anilino]methylidene]-2-phenyl-5-oxazolone | (4Z)-4-[[[4-(dimethylamino)phenyl]amino]methylidene]-2-phenyl-1,3-oxazol-5-one | 4-[1-(4-Dimethylamino-phenylamino)-meth-(Z)-ylidene]-2-phenyl-4H-oxazol-5-one | MLS000077184 | SMR000009577 | cid_5378674
Type:
Small organic molecule
Emp. Form.:
C18H17N3O2
Mol. Mass.:
307.3465
SMILES:
CN(C)c1ccc(cc1)N=Cc1nc(oc1O)-c1ccccc1 |w:9.9|
Structure:
Search PDB for entries with ligand similarity: