Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83469
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83469
Synonyms:
(5Z)-3-ethyl-5-(1-ethyl-2-quinolinylidene)-2-sulfanylidene-4-oxazolidinone | (5Z)-3-ethyl-5-(1-ethyl-2-quinolylidene)-2-thioxo-oxazolidin-4-one | (5Z)-3-ethyl-5-(1-ethylquinolin-2-ylidene)-2-sulfanylidene-1,3-oxazolidin-4-one | 3-Ethyl-5-[1-ethyl-1H-quinolin-(2Z)-ylidene]-2-thioxo-oxazolidin-4-one | MLS000068950 | SMR000008534 | cid_3098234
Type:
Small organic molecule
Emp. Form.:
C16H16N2O2S
Mol. Mass.:
300.375
SMILES:
CCN1C(=S)O\C(C1=O)=C1\C=Cc2ccccc2N1CC |c:11|
Structure:
Search PDB for entries with ligand similarity: