Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83473
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83473
Synonyms:
4-[5-(3-methoxyphenyl)-1,7-dihydro-[1,2,3,4]tetrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethyl-aniline | 4-[5-(3-methoxyphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylaniline | MLS000077686 | SMR000035047 | [4-[5-(3-methoxyphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidin-7-yl]phenyl]-dimethyl-amine | cid_5389474
Type:
Small organic molecule
Emp. Form.:
C19H20N6O
Mol. Mass.:
348.4017
SMILES:
COc1cccc(c1)C1=Nc2nnnn2C(C1)c1ccc(cc1)N(C)C |t:9|
Structure:
Search PDB for entries with ligand similarity: