Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83486
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83486
Synonyms:
MLS000115322 | N,N-dimethyl-4-[5-(4-methylphenyl)-1,7-dihydro-[1,2,3,4]tetrazolo[1,5-a]pyrimidin-7-yl]aniline | N,N-dimethyl-4-[5-(4-methylphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidin-7-yl]aniline | SMR000092467 | cid_5309765 | dimethyl-[4-[5-(p-tolyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidin-7-yl]phenyl]amine
Type:
Small organic molecule
Emp. Form.:
C19H20N6
Mol. Mass.:
332.4023
SMILES:
CN(C)c1ccc(cc1)C1CC(=Nc2nnnn12)c1ccc(C)cc1 |c:12|
Structure:
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