Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83493
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83493
Synonyms:
3-Amino-6-methyl-thieno[2,3-b]quinoline-2-carboxylic acid (furan-2-ylmethyl)-amide | 3-amino-N-(2-furanylmethyl)-6-methyl-2-thieno[2,3-b]quinolinecarboxamide | 3-amino-N-(2-furfuryl)-6-methyl-thieno[2,3-b]quinoline-2-carboxamide | 3-amino-N-(furan-2-ylmethyl)-6-methylthieno[2,3-b]quinoline-2-carboxamide | 3-azanyl-N-(furan-2-ylmethyl)-6-methyl-thieno[2,3-b]quinoline-2-carboxamide | MLS000527086 | SMR000117560 | cid_865562
Type:
Small organic molecule
Emp. Form.:
C18H15N3O2S
Mol. Mass.:
337.396
SMILES:
Cc1ccc2nc3sc(C(=O)NCc4ccco4)c(N)c3cc2c1
Structure:
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