Target
Endoribonuclease toxin MazF
Ligand
BDBM75969
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
57900±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM75969
Synonyms:
MLS000536380 | N-(3-chlorophenyl)-4-(3-methyl-4-oxidanylidene-phthalazin-1-yl)benzamide | N-(3-chlorophenyl)-4-(3-methyl-4-oxo-1-phthalazinyl)benzamide | N-(3-chlorophenyl)-4-(3-methyl-4-oxo-3,4-dihydro-1-phthalazinyl)benzamide | N-(3-chlorophenyl)-4-(3-methyl-4-oxophthalazin-1-yl)benzamide | N-(3-chlorophenyl)-4-(4-keto-3-methyl-phthalazin-1-yl)benzamide | SMR000143417 | cid_1292429
Type:
Small organic molecule
Emp. Form.:
C22H16ClN3O2
Mol. Mass.:
389.834
SMILES:
Cn1nc(-c2ccc(cc2)C(=O)Nc2cccc(Cl)c2)c2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: