Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM44490
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM44490
Synonyms:
(3Z)-1-ethyl-6-(6-oxidanylidene-4,5-dihydro-1H-pyridazin-3-yl)-3-[[2-(phenylmethylidene)hydrazinyl]methylidene]indol-2-one | (3Z)-1-ethyl-6-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-3-[[2-(phenylmethylene)hydrazinyl]methylidene]-2-indolone | (3Z)-3-[(2-benzylidenehydrazinyl)methylidene]-1-ethyl-6-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)indol-2-one | (3Z)-3-[(N'-benzalhydrazino)methylene]-1-ethyl-6-(6-keto-4,5-dihydro-1H-pyridazin-3-yl)oxindole | MLS000530557 | SMR000135537 | benzaldehyde {[1-ethyl-2-oxo-6-(6-oxo-1,4,5,6-tetrahydro-3-pyridazinyl)-1,2-dihydro-3H-indol-3-ylidene]methyl}hydrazone | cid_9552009
Type:
Small organic molecule
Emp. Form.:
C22H21N5O2
Mol. Mass.:
387.4344
SMILES:
CCN1C(=O)C(C=NN=Cc2ccccc2)c2ccc(cc12)C1=NNC(=O)CC1 |w:7.7,9.9,t:25|
Structure:
Search PDB for entries with ligand similarity: